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Shock
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Shock is a failure of the circulatory
system and is a life-threatening
medical emergency. Its key feature is
inadequate blood flow to vital
organs. It is considered a syndrome (a
group of signs and symptoms
that occur together) and can arise from
any of a number of causes.
It is usually associated with low blood
pressure and decreased urine
production.
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Signs and Symptoms |
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Common signs and symptoms of shock
include the following:
- Low blood pressure, at times undetectable
- Reduced alertness and awareness,
confusion, and sleepiness
- Cold, moist, and often bluish and
pale hands and feet
- Weak and/or rapid pulse
- Rapid breathing and hyperventilation
- Decreased urine volume
- In septic shock (from overwhelming
blood infection)—shaking
chills, rapid temperature increase,
warm, flushed skin, and rapid
pulse
- In shock related to heart
problems—lung congestion, rapid
pulse, heart murmur, engorged neck
veins
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What Causes It? |
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Shock can be caused by problems with the
heart itself (cardiogenic
shock), conditions that block blood flow
to or from the heart (extracardiac
obstructive shock), severe loss of
fluids (hypovolemic shock), or
abnormal flow of fluids into the
tissues, despite normal or increased
heart function (distributive shock).
Heart problems that can cause shock
include the following:
- Heart attack (myocardial infarction)
- Rupture of the wall between the
heart's ventricles (main
pumping chambers)
- Aneurysm (bulging) in a ventricle wall
- Prolonged open heart surgery
involving heart/lung bypass
- Dysfunction or inflammation of the
heart muscle (cardiomyopathy
or myocarditis, respectively)
- Irregular heartbeat, too rapid or
too slow
- Defective heart valves, either real
or artificial, including
narrowing of the aortic valve,
leading to decreased blood flow
from the heart
- Increased thickness of the wall of
one of the ventricles, blocking
blood flow out of the heart
Extracardiac obstructive shock can result
from the following:
- Pericardial tamponade (buildup of
fluid that puts pressure on
the heart, preventing it from
filling with enough blood)
- Massive pulmonary embolism (blockage
of blood flow to the lungs
by a blood clot, gas bubble, bit of
tissue, or other object)
- Tension pneumothorax (collapse of
the lungs caused by air that
collects outside them due to a
rupture in the lungs or chest wall)
- Severe high blood pressure in the
vessels coursing through the lungs
Hypovolemic shock can result from the following:
- Severe bleeding from an injury or
disease process
- Severe loss of fluids, as from
prolonged vomiting or diarrhea,
or from extensive burns
- Diabetes insipidus (a metabolic
disorder that causes extreme
thirst and urine output)
Distributive shock can result from the following:
- Bacterial infection in the blood
(septic shock)
- Drug overdose
- Anaphylaxis (severe, body-wide
allergic reaction)
- Abnormal opening of blood vessels
due to neurologic dysfunction
(neurogenic shock)
- Addisonian crisis (a severe adrenal
gland insufficiency)
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Who's Most At Risk? |
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The following conditions and
characteristics increase the risk
for shock:
- Serious injury and trauma
- Heart conditions such as heart
disease or heart attack
- Surgery
- Bacterial infection that has spread
to the blood
- Bleeding
- Loss of a large volume of fluids
from severe diarrhea or vomiting
- Excess alcohol use
- Severe anemia
- Allergic reaction to a drug, food,
or environmental exposure
- Drug overdose
- Pregnancy
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What to Expect at Your
Provider's Office |
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Shock is an emergency and requires
immediate conventional treatment.
In most cases, your healthcare provider
will diagnose shock based
on your signs, symptoms, and any
information readily available about
underlying disease or recent injury. He
or she will check blood
pressure, assess mental status (memory,
orientation, and alertness),
measure urine output and obtain urine
cultures, and order blood
tests to check heart, lung, and kidney
function and search for evidence
of sepsis (blood infection). Imaging and
other procedures—such as
X ray, electrocardiography (ECG),
echocardiography—may be
performed to check the status of the
heart. A heart catheterization
may also be used to determine the cause
and severity of the individual
case of shock.
Under the concepts of functional
medicine, assessment is oriented
toward determining what is impeding your
body's ability to function
normally. While some of the conventional
medical approaches may
help in this determination, they may not
necessarily apply to a
functional approach. Your healthcare
provider will determine which
assessment tools are most helpful in
establishing a treatment strategy
specific to your health needs.
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Treatment Options |
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Prevention |
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To help prevent shock, people should have
heart disease and other
conditions that may predispose them to
shock appropriately treated.
Those who have severe allergies should
avoid allergens that may
trigger anaphylactic shock and carry
self-injectable epinephrine
to treat anaphylaxis.
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Treatment Plan |
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The main goals of treatment are to
maintain blood pressure and
to make sure the person's vital
organs get enough blood and oxygen.
First aid for shock includes laying the
person down, raising the
legs to help blood return to the heart,
stopping any bleeding, ensuring
warmth, and performing cardiopulmonary
resuscitation (CPR), if needed.
Emergency medical staff will administer
oxygen and, in the case
of hypovolemic and septic shock,
intravenous fluids.
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Surgical and Other Procedures |
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Depending on the cause of shock, surgery
may be required to repair
heart valves or rupture of a ventricle,
artificially augment blood
flow from the heart, or remove an embolism.
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Complementary and
Alternative Therapies |
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Shock is always life-threatening and
requires emergency conventional
care. Some CAM therapies, however, may
be helpful as an adjunct
to conventional treatment. For instance,
certain nutrients may help
protect against the harmful effects of
shock and improve the outcome.
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Nutrition |
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Oxidative stress (damage to cells caused
by the body's normal use
of oxygen) may play a role in shock.
Several studies have suggested
that treatment with antioxidants that
help rid the body of free
radicals (harmful by-products of the
oxidative process) may protect
against some types of shock. Other
nutrients may also be protective.
- Carnitine may be helpful in treating
cardiogenic, septic, and
hypovolemic shock. A study of 115
patients with septic, cardiac,
or traumatic shock showed that
acetyl-L-carnitine helped improve
the conditions of patients with all
three types of shock. Improvements
included returning heart rate and
blood pressure to normal and
boosting oxygen delivery throughout
the body. L-carnitine has
also been reported to prevent
cardiogenic shock in people
suffering from a
heart attack.
- Coenzyme Q10 (CoQ10), an
antioxidant, may be beneficial in
treating
hypovolemic and septic shock. One
study of hemorrhagic
(bleeding-related)
shock in animals showed that CoQ10
helped protect lung function
and improve blood flow. A study on
animals with septic shock showed
that CoQ10 improved heart function,
blood flow, and blood pressure;
another suggested that pretreatment
with CoQ10 improved lung function
of the animals who later developed
septic shock.
- Glutamine added to parenteral
nutrition (nutrients given through
the veins when someone cannot take
oral nutrition) may protect
the intestines and prevent
complications from septic shock.
This addition of
glutamine has been reported to
decrease deaths among
critically ill patients and is
thought to be safe when used along
with standard treatment.
- N-acetylcysteine (NAC) improved the
immune system response in
mice that had septic shock caused by
endotoxins (toxins released
from bacterial cells). It is not
clear what this means for preventing
or treating shock in humans.
- Omega-3 Fatty Acids -- Animal
studies investigating the role
of essential fatty acids in the
outcomes from shock show positive
effects from omega-3 essential fatty
acids and negative effects
from omega-6 essential fatty acids.
Omega-3 fatty acids appear
to fight inflammation, while omega-6
fatty acids appear to promote
it. Studies of rats and guinea pigs
suggest a diet rich in
polyunsaturated
omega-3 fatty acids compared with
omega-6 fatty acids may protect
against the harmful effects of
septic shock. Diets of people in
the United States and other
industrialized countries tend to be
high in omega-6 and low in omega-3
fatty acids.
- Vitamins B3
-- At least two animal
studies have
suggested that nicotinamide (a form
of vitamin B3)
may help protect against bacterial
endotoxin that causes septic
shock. In one study, mice that were
given nicotinamide after being
injected with endotoxin were more
likely to survive than were
mice that did not receive
nicotinamide. In another study of
rats that had
endotoxic shock, blood pressure
improved in those that
received nicotinamide compared to
those that did not receive this
supplement.
- Vitamin B12 -- Studies in
animals with endotoxic
shock suggest that blood pressure
may be improved in that clinical
situation by taking hydroxocobalamin
(a form of vitamin B12).
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Herbs |
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Plant-based medicines that support the
immune system may be beneficial
in treating septic shock. For instance,
an Ayurvedic formula containing
the following ingredients helped reduce
the blood levels of bacteria
in rats infected with Escherichia
coli (an infection that
can spread to the bloodstream,
potentially causing septic
shock) compared
to rats that received a placebo:
- Ashwagandha (Withania somnifera)
- Indian gooseberry (Phyllanthus emblica)
- Sweet basil (Ocimum sanctum)
- Tamarisk (Tinospora cordifolia)
A series of newly developed herbal
remedies based on traditional
Chinese medicine were evaluated for use
in 183 people with septic
shock. Injections of the following herbs
thought to regulate the
flow of qi (life energy),
appeared to promote blood circulation
and help prevent failure of the
circulatory system as well as lower
the death rate significantly in the
treatment group compared to
the control group:
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Kangjue tongmai
-
Yiqi huiyang
-
Yiqi jiuyin
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Homeopathy |
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Scientific studies of homeopathic
remedies for the treatment of
shock specifically have not been
conducted. The remedy Aconite,
however, is often used by homeopathic
doctors for emergency conditions.
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Acupuncture |
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In animals with hypovolemic shock from
bleeding, electroacupuncture
(small electrical currents applied to
acupuncture needles) raised
blood pressure, protected cardiac
function, and normalized the levels
of various protective substances in
blood. On the other hand, there
have been four case reports of death
from shock secondary to acupuncture
– one from infection leading to septic
shock and the other
three caused by bleeding from the heart
leading to hypovolemic shock.
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Prognosis/Possible Complications |
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In most cases, the outcome of shock
depends on receiving immediate
and proper treatment. If attended to
early, shock is reversible
in many cases depending on its cause.
Immediate treatment for anaphylactic
shock, for example, usually results in
complete recovery. But any
case of shock is life threatening,
regardless of its cause, particularly
in the elderly. Shock often causes organ
damage (including the kidneys,
brain, and liver), cardiac arrest, and
respiratory failure.
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Following Up |
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Those who have suffered from shock will
most likely be admitted
to intensive care. Following treatment,
the healthcare provider
may carefully monitor the person's
condition, including temperature,
blood pressure, cardiac function, urine
flow, blood chemistry, and
blood cells.
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Supporting Research |
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Berkow R, Fletcher AJ, Beers MH, eds.
The Merck Manual.
Rahway, NJ: Merck & Co.; 1992:437-443.
Bochan M. Hypersensitivity reactions,
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Geibel J, Griffing GT, et al, eds.
Medicine, Ob/Gyn, Psychiatry,
and Surgery: An On-line Medical
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on August 29, 2000.
Corbucci GG, Loche F. L-carnitine in
cardiogenic shock therapy:
pharmacodynamic aspects and clinical
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De la Fuente M, Victor VM. Anti-oxidants
as modulators of immune
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Ernst E, White AR. Acupuncture may be
associated with serious adverse
events [letter]. BMJ. 2000;320(7233):513-514.
Farolan LR, Goto M, Myers TF, Anderson
CL, Zeller WP. Perinatal
nutrition enriched with omega-3
polyunsaturated fatty acids attenuates
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Fauci AS, Braunwald E, Isselbacher KJ, et
al, eds.Harrison's
Principles of Internal Medicine
(Harrison's Online). 14th
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on February 15, 2000.
Felbinger TW, Suchner U, Goetz AE.
Treating patients with severe
sepsis [letter]. N Engl J Med.1999;341(1):56-57.
Gasparetto A, Corbucci GG, De Blasi RA,
et al. Influence of acetyl-L-carnitine
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Graber MA. Emergency medicine: shock. In:
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on October 27, 2000.
Greenberg SS, Xie J, Zatarain JM, Kapusta
DR, Miller MJ. Hydroxocobalamin
(vitamin B12a) prevents and
reverses endotoxin-induced
hypotension and mortality in rodents:
role of nitric oxide. J
Pharmacol Exp Ther. 1995;273(1):257-65.
Hirschberg Y, Shackelford A, Mascioli EA,
Babayan VK, Bistrian BR,
Blackburn GL. The response to endotoxin
in guinea pigs after
intravenous black currant seed oil.
Lipids. 1990;25(8):491-496.
Hochman JS, Sleeper LA, Webb JG, et al.
Early revascularization
in acute myocardial infarction
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on October 30, 2000.
Jack RA. Aconite—the number one shock and
fever medicine.
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Jin MW, Zhou ZY, Zhang SW. Study on
treatment of infectious shock
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gutuo [in Chinese]. Chung
Kuo Chung Hsi I Chieh Ho Tsa Chih.1995;15(10):589-592.
Kirchgatterer A, Schwarz CD, Holler E,
Punzengruber C, Hartl P,
Eber B. Cardiac tamponade following
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Kolecki P, Menckhoff C. Shock,
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B, Dronen S, et al, eds. Emergency
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on October 30, 2000.
LeClaire RD, Kell W, Bavari S, Smith TJ,
Hunt RE. Protective effects
of niacinamide in staphylococcal
enterotoxin-B-induced toxicity.
Toxicology. 1996;107(1):69-81.
Lelli JL, Drongowski RA, Gastman B,
Remick DG, Coran AG. Effects
of Coenzyme Q10 on the mediator cascade
of sepsis. Circ Shock. 1993;39(3):178-187.
Mendez C, Jurkovich GJ, Wener MH, Garcia
I, Mays M, Maier RV. Effects
of supplemental dietary arginine, canola
oil, and trace elements
on cellular immune function in
critically injured patients.
Shock. 1996;6(1):7-12.
Mitra SK, Gupta M, Suryanarayana T, Sarma
DN. Immunoprotective
effect of IM-133. Int J
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National Heart, Lung, and Blood
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Cardiogenic
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on October 30, 2000.
Song X, Tang Z, Hou Z, Zhu S. An
experimental study on acupuncture
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Med. 1993;13(3):207-210.
Toth PP. Cardiology: acute pulmonary
edema. In:University
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3rd ed.Accessed at
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on October 30, 2000.
Victor VV, Guayerbas N, Puerto M, Medina
S, De la Fuente M. Ascorbic
acid modulates in vitro the function of
macrophages from mice with
endotoxic shock.
Immunopharmacology. 2000;46(1):89-101.
Weimann A, Bastian L, Bischoff WE, et al.
Influence of arginine,
omega-3 fatty acids and
nucleotide-supplemented enteral support
on systemic inflammatory response
syndrome and multiple organ failure
in patients after severe trauma.
Nutrition.
1998;14(2):165-172.
Winter BK, Fiskum G, Gallo LL. Effects of
L-carnitine on serum
triglyceride and cytokine levels in rat
models of cachexia and septic
shock. Br J Cancer.1995;72(5):1173-1179.
Yamada M. Effects of coenzyme Q10 in
hemorrhagic shock. Crit
Care Med.1990;18(5):509-514.
Zingarelli B, Salzman AL, Szabo C.
Protective effects of nicotinamide
against nitric oxide-mediated delayed
vascular failure in endotoxic
shock: potential involvement of polyADP
ribosyl synthetase. Shock. 1996;5(4):258-264.
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Copyright © 2001 OneMedicine
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